There’s nothing to fix, the balance of BCAAs in Huel products is ideal and we have other Hueligans who want a higher amount of BCAAs.
The study you cited looked at varying BCAAs as a ratio to other amino acids in mice. The macronutrient ratio used is not similar to any Huel product “18% total protein, 64% carbohydrate, 18% fat”.
When you look at the diets of the mice one possible conclusion is that an imbalance of BCAAs in a highly processed Western diet could contribute to overeating and the authors suggest this is because the mice are trying to get enough non-BCAAs in their diet. Such a diet could be achieved in humans is by eating a poor diet and supplementing with BCAAs.
This is the complete opposite of what was reported in the paper. “Despite no increase in hepatic mTOR activation” and “Our results suggest that the negative health and lifespan costs of long-term high BCAA: non-BCAA diets are a consequence of hyperphagia and obesity”. The affect on mice lifespan was due to overeating and calorie excess.
The regular Huel version is high in protein, and now there’s Huel Black that’s even higher in protein. High protein stimulates mTOR and over the long term has negative health consequences. A lower protein version would be better for those who are interested in longevity versus weight loss.
I doubt that taking out a single factor explains anything in complex systems like metabolism. You have to get a systems perspective, where there are various cross relations and feedback loops that have to be taken into account.
In my opinion psychological factors are not sufficiently taken into account here. With lab mices it’s easy, they can just eat what they are given. For humans it may be the best strategy to aim for avoiding being hungry or inducing “bad” cravings. With more protein this is easier, leading to a lower calorie consumption. Which is a much-celebrated strategy for lonevity with various studies “demonstrating” its positive effects.
Maybe the best “strategy” is just trying what works for you and then stick to it. Reading a scientific article is one thing, but doing what feels best, feeling good is something totally different. Maybe we just have to get a good intuition on what works best for us, and not more publications “demonstrating” X with equally as many studies “demonstrating” non-X…